Lectin-reactive anti-α-gal in patients with Crohn's disease: correlation with clinical phenotypes.

ABSTRACT:

Background

Patients with inflammatory bowel disease have higher proportions of immunoglobulin G (IgG) antibodies lacking N-galactose, also called agalactosyl IgG, in their serum. Such agalactosyl IgGs have been associated with disease activity and the immunogenicity of biologics. The aim was to describe the relationship between circulating levels of a subset of agalactosyl IgGs (anti-α-Gal) and Crohn's disease (CD) phenotypes.

Methods

Prospectively collected serum samples of a well-characterized cohort of patients with inflammatory bowel disease and controls were used. Serum anti-α-Gal levels were measured by a high-affinity enzyme-linked immunosorbent assay and referenced to a standard control.

Results

Serum samples from 167 subjects were tested; 62 with CD, 76 with

SUBMITTER: Safaie P 

PROVIDER: S-EPMC4112456 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature