Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.

ABSTRACT:

Context

Selective serotonin reuptake inhibitors are widely prescribed for children with autism spectrum disorders.

Objectives

To determine the efficacy and safety of citalopram hydrobromide therapy for repetitive behavior in children with autism spectrum disorders.

Design

National Institutes of Health-sponsored randomized controlled trial.

Setting

Six academic centers, including Mount Sinai School of Medicine, North Shore-Long Island Jewish Health System, University of North Carolina at Chapel Hill, University of California at Los Angeles, Yale University, and Dartmouth Medical School.

Participants

One hundred forty-nine volunteers 5 to 17 years old (mean [SD] age, 9.4 [3.1] years) were randomized to receive citalopram (n = 73) or placebo (n = 76). Parti

SUBMITTER: King BH 

PROVIDER: S-EPMC4112556 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature