A systems biology analysis of brain microvascular endothelial cell lipotoxicity.

ABSTRACT:

Background

Neurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world. Lipotoxicity is a metabolic disorder that results from accumulation of lipids, particularly fatty acids, in non-adipose tissue leading to cellular dysfunction, lipid droplet formation, and cell death.

Results

Our studies indicate for the first time that the neurovascular circulation also can manifest lipotoxicity, which could have major effects on cognitive function. The penetration of integrative systems biology approaches is limited in this area of research, which reduces our capacity to gain an objective insight into the signal transduction and re

SUBMITTER: Aung HH 

PROVIDER: S-EPMC4112729 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature