Insights into reference point indentation involving human cortical bone: sensitivity to tissue anisotropy and mechanical behavior.

ABSTRACT: Reference point indentation (RPI) is a microindentation technique involving 20 cycles of loading in "force-control" that can directly assess a patient׳s bone tissue properties. Even though preliminary clinical studies indicate a capability for fracture discrimination, little is known about what mechanical behavior the various RPI properties characterize and how these properties relate to traditional mechanical properties of bone. To address this, the present study investigated the sensitivity of RPI properties to anatomical location and tissue organization as well as examined to what extent RPI measurements explain the intrinsic mechanical properties of human cortical bone. Multiple indents with a target force of 10N were done in 2 orthogonal directions (longitudinal and transverse) per qu

SUBMITTER: Granke M 

PROVIDER: S-EPMC4112765 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature