Magnetic resonance-guided focused ultrasound for patients with painful bone metastases: phase III trial results.

ABSTRACT: Pain due to bone metastases is a common cause of cancer-related morbidity, with few options available for patients refractory to medical therapies and who do not respond to radiation therapy. This study assessed the safety and efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS), a noninvasive method of thermal tissue ablation for palliation of pain due to bone metastases. Patients with painful bone metastases were randomly assigned 3:1 to receive MRgFUS sonication or placebo. The primary endpoint was improvement in self-reported pain score without increase of pain medication 3 months after treatment and was analyzed by Fisher's exact test. Components of the response composite, Numerical Rating Scale for pain (NRS) and morphine equivalent daily dose intake, were analyz

SUBMITTER: Hurwitz MD 

PROVIDER: S-EPMC4112926 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature