Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis.

ABSTRACT:

Background

Vasohibin-2 (VASH2) has been identified as an endogenous and vascular endothelial growth factor (VEGF)-independent angiogenic factor that is highly expressed in tumor cells. In the present study, we aimed to determine whether pre-existing vascular changes can be used to predict tumor transformation as benign or malignant. We sought to characterize microvascular changes and tumor development in the intestinal tract of ApcMin/+ mice and ApcMin/+/Vash2-/- mice.

Methods

ApcMin/+ mice provide a unique orthotopic model for the development of spontaneous adenomatous polyposis and subsequent carcinomas, a phenomenon termed the adenoma-carcinoma sequence. ApcMin/+ mice were mated with Vash2-/- mice with a mixed C57BL/6 background and the resulting pups were screened for th

SUBMITTER: Kitahara S 

PROVIDER: S-EPMC4113181 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature