Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.

ABSTRACT: We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.

SUBMITTER: Kim JG 

PROVIDER: S-EPMC4113214 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature