The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine.

ABSTRACT:

Background

Whole genome sequencing (WGS) is already being used in certain clinical and research settings, but its impact on patient well-being, health-care utilization, and clinical decision-making remains largely unstudied. It is also unknown how best to communicate sequencing results to physicians and patients to improve health. We describe the design of the MedSeq Project: the first randomized trials of WGS in clinical care.

Methods/design

This pair of randomized controlled trials compares WGS to standard of care in two clinical contexts: (a) disease-specific genomic medicine in a cardiomyopathy clinic and (b) general genomic medicine in primary care. We are recruiting 8 to 12 cardiologists, 8 to 12 primary care physicians, and approximately 200 of their patients. Patient

SUBMITTER: Vassy JL 

PROVIDER: S-EPMC4113228 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature