Predicting risk of upper gastrointestinal bleed and intracranial bleed with anticoagulants: cohort study to derive and validate the QBleed scores.

ABSTRACT:

Objective

To develop and validate risk algorithms (QBleed) for estimating the absolute risk of upper gastrointestinal and intracranial bleed for patients with and without anticoagulation aged 21-99 years in primary care.

Design

Open cohort study using routinely collected data from general practice linked to hospital episode statistics data and mortality data during the five year study period between 1 January 2008 and 1 October 2013.

Setting

565 general practices in England contributing to the national QResearch database to develop the algorithm and 188 different QResearch practices to validate the algorithm. All 753 general practices had data linked to hospital episode statistics and mortality data at individual patient level.

Endpoint

Gastrointestinal bleed a

SUBMITTER: Hippisley-Cox J 

PROVIDER: S-EPMC4113281 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature