Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration.

ABSTRACT: Rapid advancements in the field of stem cell biology have led to many current efforts to exploit stem cells as therapeutic agents in regenerative medicine. However, current ex vivo cell manipulations common to most regenerative approaches create a variety of technical and regulatory hurdles to their clinical translation, and even simpler approaches that use exogenous factors to differentiate tissue-resident stem cells carry significant off-target side effects. We show that non-ionizing, low-power laser (LPL) treatment can instead be used as a minimally invasive tool to activate an endogenous latent growth factor complex, transforming growth factor-β1 (TGF-β1), that subsequently differentiates host stem cells to promote tissue regeneration. LPL treatment induced reactive oxygen species (ROS

SUBMITTER: Arany PR 

PROVIDER: S-EPMC4113395 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature