Divergent total syntheses of lyconadins A and C.

ABSTRACT: Divergent and concise total syntheses of two lycopodium alkaloids, lyconadins A and C have been developed. The synthesis of lyconadin A, having potent neurotrophic activity, features an efficient one-pot ketal removal and formal aza-[4+2] cyclization to form the cagelike core structure. A tandem ketal removal/Mannich reaction was developed to build the tricyclic structure of lyconadin C. Both lyconadins A and C were synthesized from a pivotal intermediate.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4113559 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature