Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human breast cancer.

ABSTRACT:

Background

Non-coding RNAs (ncRNAs) are emerging as key regulators of many cellular processes in both physiological and pathological states. Moreover, the constant discovery of new non-coding RNA species suggests that the study of their complex functions is still in its very early stages. This variegated class of RNA species encompasses the well-known microRNAs (miRNAs) and the most recently acknowledged long non-coding RNAs (lncRNAs). Interestingly, in the last couple of years, a few studies have shown that some lncRNAs can act as miRNA sponges, i.e. as competing endogenous RNAs (ceRNAs), able to reduce the amount of miRNAs available to target messenger RNAs (mRNAs).

Results

We propose a computational approach to explore the ability of lncRNAs to act as ceRNAs by protecting

SUBMITTER: Paci P 

PROVIDER: S-EPMC4113672 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature