Evaluation of circulating miRNAs in wet age-related macular degeneration.

ABSTRACT:

Purpose

In the present study, we aimed to investigate the changes in plasma miRNA in patients with wet age-related macular degeneration.

Methods

The expression profiles of 384 miRNAs in plasma from 33 patients (22 male, 11 female) who were diagnosed with wet age-related macular degeneration with fundus examination, fundus fluorescein angiography, and optical coherence tomography and 31 controls (17 male, 14 female) were evaluated using high-throughput quantitative real-time PCR.

Results

Our results demonstrated that the expression level of five miRNAs (miR-17-5p, miR-20a-5p, miR-24-3p, miR-106a-5p, and miR-223-3p) was significantly upregulated in patients with age-related macular degeneration when compared to the control group (p<0.05). The expression level of 11 miRN

SUBMITTER: Ertekin S 

PROVIDER: S-EPMC4113960 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature