Structural covariance of superficial white matter in mild Alzheimer's disease compared to normal aging.

ABSTRACT:

Introduction

Interindividual variations in regional structural properties covary across the brain, thus forming networks that change as a result of aging and accompanying neurological conditions. The alterations of superficial white matter (SWM) in Alzheimer's disease (AD) are of special interest, since they follow the AD-specific pattern characterized by the strongest neurodegeneration of the medial temporal lobe and association cortices.

Methods

Here, we present an SWM network analysis in comparison with SWM topography based on the myelin content quantified with magnetization transfer ratio (MTR) for 39 areas in each hemisphere in 15 AD patients and 15 controls. The networks are represented by graphs, in which nodes correspond to the areas, and edges denote statistical ass

SUBMITTER: Carmeli C 

PROVIDER: S-EPMC4113976 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature