A common haplotype of KIAA0319 contributes to the phonological awareness skill in Chinese children.

ABSTRACT:

Background

Previous studies have shown that KIAA0319 is a candidate gene for dyslexia in western populations. In view of the different languages used in Caucasian and Chinese populations, the aim of the present study was to investigate whether there is also an association of KIAA0319 in Chinese children with dyslexia and/or to the language-related cognitive skills.

Method and results

A total of twenty six single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families. Four of the SNPs have been reported in the literature and twenty two being tag SNPs at KIAA0319. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using permutation. Results

SUBMITTER: Lim CK 

PROVIDER: S-EPMC4114142 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature