Epigenetic response in mice mastitis: Role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection.

ABSTRACT:

Background

There is renewed interest towards understanding the host-pathogen interaction in the light of epigenetic modifications. Although epithelial tissue is the major site for host-pathogen interactions, there is handful of studies to show how epithelial cells respond to pathogens. Bacterial infection in the mammary gland parenchyma induces local and subsequently systemic inflammation that results in a complex disease called mastitis. Globally Staphylococcus aureus is the single largest mastitis pathogen and the infection can ultimately result in either subclinical or chronic and sometimes lifelong infection.

Results

In the present report we have addressed the differential inflammatory response in mice mammary tissue during intramammary infection and the altered epigenet

SUBMITTER: Modak R 

PROVIDER: S-EPMC4114167 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature