Frontal cortex BOLD signal changes in premanifest Huntington disease: a possible fMRI biomarker.

ABSTRACT:

Objective

To identify a possible functional imaging biomarker sensitive to the earliest neural changes in premanifest Huntington disease (preHD), allowing early therapeutic approaches aimed at preventing or delaying clinical onset.

Methods

Sixteen preHD and 18 healthy participants were submitted to anatomical acquisitions and functional MRI (fMRI) acquisitions during the execution of the exogenous covert orienting of attention task. Due to strong a priori hypothesis, all fMRI correlation analyses were restricted to the following: (1) the frontal oculomotor cortex identified by the means of a prosaccadic task, comprising frontal eye fields and supplementary frontal eye fields; and (2) the data collected during inhibition of return, a phenomenon occurring during the executed t

SUBMITTER: Ferraro S 

PROVIDER: S-EPMC4114171 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature