Longitudinal changes in task-evoked brain responses in Parkinson's disease patients with and without mild cognitive impairment.

ABSTRACT: Cognitive deficits are common in Parkinson's disease. Previous cross-sectional research has demonstrated a link between cognitive impairments and fronto-striatal dopaminergic dysmodulation. However, longitudinal studies that link disease progression with altered task-evoked brain activity are lacking. Therefore, our objective was to longitudinally evaluate working-memory related brain activity changes in Parkinson's disease patients with and without mild cognitive impairment (MCI). Patients were recruited within a longitudinal cohort study of incident patients with idiopathic parkinsonism. We longitudinally (at baseline examination and at 12-months follow-up) compared 28 patients with Parkinson's disease without MCI with 11 patients with Parkinson's disease and MCI. Functional MRI blood ox

SUBMITTER: Ekman U 

PROVIDER: S-EPMC4114183 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature