1D-3D hybrid modeling-from multi-compartment models to full resolution models in space and time.

ABSTRACT: Investigation of cellular and network dynamics in the brain by means of modeling and simulation has evolved into a highly interdisciplinary field, that uses sophisticated modeling and simulation approaches to understand distinct areas of brain function. Depending on the underlying complexity, these models vary in their level of detail, in order to cope with the attached computational cost. Hence for large network simulations, single neurons are typically reduced to time-dependent signal processors, dismissing the spatial aspect of each cell. For single cell or networks with relatively small numbers of neurons, general purpose simulators allow for space and time-dependent simulations of electrical signal processing, based on the cable equation theory. An emerging field in Computational Neur

SUBMITTER: Grein S 

PROVIDER: S-EPMC4114301 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature