Synthetic studies on lemonomycin: construction of the tetracyclic core.

ABSTRACT: A substrate-induced stereocontrol strategy was used to gain access to the tetracyclic core of (-)-lemonomycin. An advanced intermediate was prepared from a known substituted tyrosinol through a 16-step sequence, which involved a Pictet-Spengler reaction, a [3+2] dipolar cycloaddition and an enamide hydrogenation.

SUBMITTER: Jimenez-Somarribas A 

PROVIDER: S-EPMC4114395 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature