2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.

ABSTRACT: 2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.

SUBMITTER: Rynearson KD 

PROVIDER: S-EPMC4114401 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature