Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

ABSTRACT:

Background

Bronchial thermoplasty (BT) has previously been shown to improve asthma control out to 2 years in patients with severe persistent asthma.

Objective

We sought to assess the effectiveness and safety of BT in asthmatic patients 5 years after therapy.

Methods

BT-treated subjects from the Asthma Intervention Research 2 trial (ClinicalTrials.govNCT01350414) were evaluated annually for 5 years to assess the long-term safety of BT and the durability of its treatment effect. Outcomes assessed after BT included severe exacerbations, adverse events, health care use, spirometric data, and high-resolution computed tomographic scans.

Results

One hundred sixty-two (85.3%) of 190 BT-treated subjects from the Asthma Intervention Research 2 trial completed 5 years of

SUBMITTER: Wechsler ME 

PROVIDER: S-EPMC4114404 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature