Maternal smoking during pregnancy and offspring smoking initiation: assessing the role of intrauterine exposure.

ABSTRACT:

Aims

To assess whether associations between maternal smoking during pregnancy and offspring smoking initiation are due to intrauterine mechanisms.

Design

Comparison of associations of maternal and partner smoking behaviour during pregnancy with offspring smoking initiation using partner smoking as a negative control (n = 6484) and a Mendelian randomization analysis (n = 1020), using a genetic variant in the mothers as a proxy for smoking cessation during pregnancy.

Setting

A longitudinal birth cohort in South West England.

Participants

Participants of the Avon Longitudinal Study of Parents and Children (ALSPAC).

Measurements

Smoking status during pregnancy was self-reported by mother and partner in questionnaires administered at pregnancy. Latent classes

SUBMITTER: Taylor AE 

PROVIDER: S-EPMC4114534 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature