Cytokine gene variation is associated with depressive symptom trajectories in oncology patients and family caregivers.

ABSTRACT:

Purpose

Depressive symptoms are common in cancer patients and their family caregivers (FCs). While these symptoms are characterized by substantial interindividual variability, the factors that predict this variability remain largely unknown. This study sought to confirm latent classes of oncology patients and FCs with distinct depressive symptom trajectories and to examine differences in phenotypic and genotypic characteristics among these classes.

Method

Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on Center for Epidemiological Studies-Depression (CES-D) scores obtained prior to, during, and for four months following completion of radiat

SUBMITTER: Dunn LB 

PROVIDER: S-EPMC4114773 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature