An Abp1-dependent route of endocytosis functions when the classical endocytic pathway in yeast is inhibited.

ABSTRACT: Clathrin-mediated endocytosis (CME) is a well characterized pathway in both yeast and mammalian cells. An increasing number of alternative endocytic pathways have now been described in mammalian cells that can be both clathrin, actin, and Arf6- dependent or independent. In yeast, a single clathrin-mediated pathway has been characterized in detail. However, disruption of this pathway in many mutant strains indicates that other uptake pathways might exist, at least for bulk lipid and fluid internalization. Using a combination of genetics and live cell imaging, here we show evidence for a novel endocytic pathway in S. cerevisiae that does not involve several of the proteins previously shown to be associated with the 'classic' pathway of endocytosis. This alternative pathway functions in the p

SUBMITTER: Aghamohammadzadeh S 

PROVIDER: S-EPMC4114835 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature