Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults.

ABSTRACT:

Objective

Redox status and inflammation are important in the pathophysiology of numerous chronic diseases. Epidemiological studies have linked vitamin D status to a number of chronic diseases. We aimed to examine the relationships between serum 25-hydroxyvitamin D [25(OH)D] and circulating thiol/disulphide redox status and biomarkers of inflammation.

Design

This was a cross-sectional study of N = 693 adults (449 females, 244 males) in an apparently healthy, working cohort in Atlanta, GA. Plasma glutathione (GSH), cysteine (Cys) and their associated disulphides were determined with high-performance liquid chromatography, and their redox potentials (Eh GSSG and Eh CySS) were calculated using the Nernst equation. Serum inflammatory markers included interleukin-6 (IL-6), interle

SUBMITTER: Alvarez JA 

PROVIDER: S-EPMC4115025 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature