Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk.

ABSTRACT:

Purpose

Osteosarcoma is the most common childhood bone cancer. Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. Whether genetic polymorphisms of IL-1B also influence osteosarcoma risk is unknown. The aim of this study was to investigate the association between IL-1B gene polymorphisms and osteosarcoma risk in Chinese Han patients.

Methods

A hospital-based case-control study involving 120 osteosarcoma patients and 120 controls was conducted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect three IL-1B gene polymorphisms (-31 T/C, -511 C/T and +3954 C/T) in these patients.

Results

Patients with osteosarcoma had a significantly lower frequency of -31 CC genotype [odds ratio (OR)

SUBMITTER: He Y 

PROVIDER: S-EPMC4115099 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature