Population red blood cell folate concentrations for prevention of neural tube defects: Bayesian model.

ABSTRACT:

Objective

To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects.

Design

Bayesian model.

Setting

Data from two population based studies in China.

Participants

247,831 participants in a prospective community intervention project in China (1993-95) to prevent neural tube defects with 400 μg/day folic acid supplementation and 1194 participants in a population based randomized trial (2003-05) to evaluate the effect of folic acid supplementation on blood folate concentration among Chinese women of reproductive age.

Intervention

Folic acid supplementation (400 μg/day).

Main outcome measures

Estimated RBC folate concentration at time of neural tube closure (day 28 of gestation) and ris

SUBMITTER: Crider KS 

PROVIDER: S-EPMC4115151 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature