Establishment and characterization of a highly tumorigenic African American prostate cancer cell line, E006AA-hT.

ABSTRACT: Genuine racial differences in prostate cancer (PCa) biology have been considered among the potential reasons to explain PCa disparities. There is no animal model to represent all aspects of human PCa and, more specifically, to be used for PCa disparity research. The lack of a spontaneously transformed in vitro cell-based model system has been a significant impediment to investigating and understanding potential molecular mechanisms, and the hormonal, genetic, and epigenetic factors underlying the biological and clinical aggressiveness of PCa in African American (AA) men. In this study, we established and characterized the E006AA-hT cell line as a highly tumorigenic subline of the previously characterized primary AA-PCa cell line, E006AA. Extensive characterization of the E006AA-hT cell lin

SUBMITTER: Koochekpour S 

PROVIDER: S-EPMC4115195 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature