Analysis of the placental tissue transcriptome of normal and preeclampsia complicated pregnancies.

ABSTRACT: Preeclampsia is one of the most severe gestational complications which is one of the leading causes of maternal and perinatal morbidity and mortality. A growth in the incidence of severe and combined forms of the pathology has been observed in recent years. According to modern concepts, inadequate cytotrophoblast invasion into the spiral arteries of the uterus and development of the ischemia-reperfusion syndrome in the placental tissue play the leading role in the development of preeclampsia, which is characterized by multipleorgan failure. In this regard, our work was aimed at studying the patterns of placental tissue transcriptome that are specific to females with PE and with physiological pregnancy, as well as identifying the potential promising biomarkers and molecular mechanisms of th

SUBMITTER: Trifonova EA 

PROVIDER: S-EPMC4115229 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature