Allopregnanolone levels and seizure frequency in progesterone-treated women with epilepsy.

ABSTRACT:

Objective

To determine whether allopregnanolone (AP) may mediate seizure reduction in progesterone-treated women with epilepsy.

Methods

The NIH Progesterone Trial compared the efficacy of adjunctive cyclic natural progesterone therapy vs placebo treatment of intractable seizures in 294 subjects, randomized 2:1 to progesterone or placebo, stratified by catamenial vs noncatamenial designation. Treatments were compared on proportions of 50% responders, and changes in seizure frequency from 3 baseline to 3 treatment cycles. Serum AP levels were measured by radioimmunoassay from 155 women with intractable focal-onset seizures who had baseline and treatment-phase midluteal serum samples drawn each cycle for hormone measurements.

Results

There was no significant correlation

SUBMITTER: Herzog AG 

PROVIDER: S-EPMC4115601 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature