APOE polymorphisms and cognitive functions in patients with brain tumors.

ABSTRACT:

Objective

The goal of this study was to assess whether the APOE ε4 allele and other APOE single nucleotide polymorphisms (SNPs) influence neuropsychological and neuroimaging outcomes in patients with brain tumors.

Methods

Two hundred eleven patients with brain tumors participated in the study. All patients completed standardized neuropsychological tests and provided a blood sample for APOE genotyping. Ratings of white matter abnormalities were performed on MRI scans. Patients were classified into 2 groups based on the presence (n = 50) or absence (n = 161) of at least one APOE ε4 allele. Additional APOE SNPs were genotyped in a subset of 150 patients.

Results

Patients with at least one APOE ε4 allele had significantly lower scores in verbal learning and delayed recall

SUBMITTER: Correa DD 

PROVIDER: S-EPMC4115606 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature