Structural network efficiency is associated with cognitive impairment in small-vessel disease.

ABSTRACT:

Objective

To characterize brain network connectivity impairment in cerebral small-vessel disease (SVD) and its relationship with MRI disease markers and cognitive impairment.

Methods

A cross-sectional design applied graph-based efficiency analysis to deterministic diffusion tensor tractography data from 115 patients with lacunar infarction and leukoaraiosis and 50 healthy individuals. Structural connectivity was estimated between 90 cortical and subcortical brain regions and efficiency measures of resulting graphs were analyzed. Networks were compared between SVD and control groups, and associations between efficiency measures, conventional MRI disease markers, and cognitive function were tested.

Results

Brain diffusion tensor tractography network connectivity was sig

SUBMITTER: Lawrence AJ 

PROVIDER: S-EPMC4115608 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature