Differential protein expressions in breast cancer between drug sensitive tissues and drug resistant tissues.

ABSTRACT:

Objective

To investigate the differential expression of the sensitive and resistant relative proteins in human breast cancer tissue.

Methods

A drug sensitive group and a drug resistant group for chemotherapy in patients with breast cancer were selected through neoadjuvant therapy. The differential protein expression in 2 groups was detected by proteomic techniques, and parts of differential proteins were identified by Western blotting.

Results

There were 13 differential proteins in the 2 groups, in which the expression of 3 proteins was up-regulated and 10 down-regulated. Seven proteins were identified by Western blotting. The expressions of keratin type I cytoskeletal 19 (KIC19) and thymidine phosphorylase (TYPH) were up-regulated, and the expressions of heat shock p

SUBMITTER: Yi W 

PROVIDER: S-EPMC4115728 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature