Risk factors associated with reticular pseudodrusen versus large soft drusen.

ABSTRACT:

Purpose

To investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen without reticular pseudodrusen.

Design

Prospective case-case comparison.

Methods

In a clinical practice setting, patients with AMD were sequentially screened using clinical examination and scanning laser ophthalmoscopy imaging to prospectively identify subjects (n = 73) with the phenotypes of (1) reticular pseudodrusen without large soft drusen (n = 30) or (2) large soft drusen without reticular pseudodrusen (n = 43). Subjects were genotyped for 2 alleles associated with AMD, age-related maculopathy susceptibility 2 (ARMS

SUBMITTER: Boddu S 

PROVIDER: S-EPMC4115805 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature