A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease.

ABSTRACT:

Background

Excessive apoptosis is believed to play a role in many degenerative and non-degenerative neurological diseases including Alzheimer's disease (AD). Much recent data suggest that apoptotic mechanisms may represent the missing link between Aβ deposition and proteolysis of tau protein. However, there is emerging evidence that apoptotic mechanisms may play a role in Alzheimer's Disease pathogenesis in the absence of overt apoptosis. TNF-related apoptosis inducing ligand receptor 1 (Death Receptor 4, DR4) might impair the apoptotic signal transduction and lead to dysregulation of the homeostasis between cell survival and cell death.

Aims

The aim of our study was to further investigate the relationship between genetic variants of DR4 and Alzheimer's Disease.

Study des

SUBMITTER: Edgunlu TG 

PROVIDER: S-EPMC4115907 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature