Inhibition of periostin expression protects against the development of renal inflammation and fibrosis.

ABSTRACT: Increased renal expression of periostin, a protein normally involved in embryonic and dental development, correlates with the decline of renal function in experimental models and patient biopsies. Because periostin has been reported to induce cell differentiation, we investigated whether it is also involved in the development of renal disease and whether blocking its abnormal expression improves renal function and/or structure. After unilateral ureteral obstruction in wild-type mice, we observed a progressive increase in the expression and synthesis of periostin in the obstructed kidney that associated with the progression of renal lesions. In contrast, mice lacking the periostin gene showed less injury-induced interstitial fibrosis and inflammation and were protected against structural al

SUBMITTER: Mael-Ainin M 

PROVIDER: S-EPMC4116056 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature