Oxidative modulation of voltage-gated potassium channels.

ABSTRACT:

Significance

Voltage-gated K+ channels are a large family of K+-selective ion channel protein complexes that open on membrane depolarization. These K+ channels are expressed in diverse tissues and their function is vital for numerous physiological processes, in particular of neurons and muscle cells. Potentially reversible oxidative regulation of voltage-gated K+ channels by reactive species such as reactive oxygen species (ROS) represents a contributing mechanism of normal cellular plasticity and may play important roles in diverse pathologies including neurodegenerative diseases.

Recent advances

Studies using various protocols of oxidative modification, site-directed mutagenesis, and structural and kinetic modeling provide a broader phenomenology and emerging mechanistic i

SUBMITTER: Sahoo N 

PROVIDER: S-EPMC4116129 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature