Structural basis for the recognition in an idiotype-anti-idiotype antibody complex related to celiac disease.

ABSTRACT: Anti-idiotype antibodies have potential therapeutic applications in many fields, including autoimmune diseases. Herein we report the isolation and characterization of AIM2, an anti-idiotype antibody elicited in a mouse model upon expression of the celiac disease-specific autoantibody MB2.8 (directed against the main disease autoantigen type 2 transglutaminase, TG2). To characterize the interaction between the two antibodies, a 3D model of the MB2.8-AIM2 complex has been obtained by molecular docking. Analysis and selection of the different obtained docking solutions was based on the conservation within them of the inter-residue contacts. The selected model is very well representative of the different solutions found and its stability is confirmed by molecular dynamics simulations. Furtherm

SUBMITTER: Vangone A 

PROVIDER: S-EPMC4116137 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature