Partial proteasome inhibitors induce hair follicle growth by stabilizing β-catenin.

ABSTRACT: The activation of tissue stem cells from their quiescent state represents the initial step in the complex process of organ regeneration and tissue repair. While the identity and location of tissue stem cells are becoming known, how key regulators control the balance of activation and quiescence remains mysterious. The vertebrate hair is an ideal model system where hair cycling between growth and resting phases is precisely regulated by morphogen signaling pathways, but how these events are coordinated to promote orderly signaling in a spatial and temporal manner remains unclear. Here, we show that hair cycle timing depends on regulated stability of signaling substrates by the ubiquitin-proteasome system. Topical application of partial proteasomal inhibitors (PaPIs) inhibits epidermal and d

SUBMITTER: Yucel G 

PROVIDER: S-EPMC4116182 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature