Identification of a novel luminal molecular subtype of breast cancer.

ABSTRACT: The molecular classification of human breast tumors has afforded insights into subtype specific biological processes, patient prognosis and response to therapies. However, using current methods roughly one quarter of breast tumors cannot be classified into one or another molecular subtype. To explore the possibility that the unclassifiable samples might comprise one or more novel subtypes we employed a collection of publically available breast tumor datasets with accompanying clinical information to assemble 1,593 transcript profiles: 25% of these samples could not be assigned to one of the current molecular subtypes of breast cancer. All of the unclassifiable samples could be grouped into a new molecular subtype, which we termed "luminal-like". We also identified the luminal-like subtype

SUBMITTER: Dvorkin-Gheva A 

PROVIDER: S-EPMC4116208 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature