A mathematical model of long-term renal sympathetic nerve activity inhibition during an increase in sodium intake.

ABSTRACT: It is well known that renal nerves directly affect renal vascular resistance, tubular sodium reabsorption, and renin secretion. Inhibition of renal sympathetic nerve activity (RSNA) decreases renal vascular resistance, tubular sodium reabsorption, and renin secretion, leading to an increase in sodium excretion. Although several studies show that inhibition of RSNA promotes sodium excretion during an acute blood volume expansion, there is limited research relating to the importance of RSNA inhibition that contributes to sodium homeostasis during a long-term increase in sodium intake. Therefore, to dissect the underlying mechanisms of sodium excretion, a mathematical model of a cardiovascular system consisting of two kidneys, each with an independent RSNA, was developed. Simulations were per

SUBMITTER: Karaaslan F 

PROVIDER: S-EPMC4116423 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature