Brachyury regulates proliferation of cancer cells via a p27Kip1-dependent pathway.

ABSTRACT: The T-box transcription factor Brachyury is expressed in a number of tumour types and has been demonstrated to have cancer inducing properties. To date, it has been linked to cancer associated induction of epithelial to mesenchymal transition, tumour metastasis and expression of markers for cancer stem-like cells. Taken together, these findings indicate that Brachyury plays an important role in the progression of cancer, although the mechanism through which it functions is poorly understood. Here we show that Brachyury regulates the potential of Brachyury-positive colorectal cancer cells to proliferate and reduced levels of Brachyury result in inhibition of proliferation, with features consistent with the cells entering a quiescent-like state. This inhibition of proliferation is dependent

SUBMITTER: Jezkova J 

PROVIDER: S-EPMC4116522 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature