OCT1 genetic variants influence the pharmacokinetics of morphine in children.

ABSTRACT:

Aim

Large interindividual variability in morphine disposition could contribute to unpredictable variability in morphine analgesia and adverse events. Caucasian children have more adverse effects and slower morphine clearance than African-American children. To study variations in intravenous morphine pharmacokinetics in children, we examined the influence of genetic polymorphisms in OCT1.

Methods

In 146 children undergoing adenotonsillectomy, 146 concentration-time profiles (2-4 measurements per patient) were available. Population pharmacokinetic analysis characterized the profiles in NONMEM(®) and tested OCT1 variants as covariates.

Results

Allometrically scaled post hoc Bayesian morphine clearance in homozygotes of loss-of-function OCT1 variants (n = 9, OCT1*2-*5/*2-

SUBMITTER: Fukuda T 

PROVIDER: S-EPMC4116670 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature