Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness.

ABSTRACT: Fatty acid synthase is up-regulated in a variety of cancers, including prostate cancer. Up-regulation of fatty acid synthase not only increases production of fatty acids in tumors but also contributes to the transformed phenotype by conferring growth and survival advantages. In addition, increased fatty acid synthase expression in prostate cancer correlates with poor prognosis, although the mechanism(s) by which this occurs are not completely understood. Because fatty acid synthase is expressed at low levels in normal cells, it is currently a major target for anticancer drug design. Fatty acid synthase is normally found in the cytosol; however, we have discovered that it also localizes to the nucleus in a subset of prostate cancer cells. Analysis of the fatty acid synthase protein sequence

SUBMITTER: Madigan AA 

PROVIDER: S-EPMC4116692 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature