Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies.

ABSTRACT: A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary disease. To gain further insights into the role of the transcriptome deregulation in the transition from a normal plasma cell to a clonal plasma cell, and from an indolent clonal plasma cell to a malignant plasma cell, we performed gene expression profiling in 20 patients with monoclonal gammopathy of undetermined significance, 33 with high-risk smoldering myeloma and 41 with multiple myeloma. The analysis showed that 126 genes were differentially expressed in monoclonal gammopathy of undetermined significance, smoldering myeloma and multipl

SUBMITTER: Lopez-Corral L 

PROVIDER: S-EPMC4116836 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature