Variations in EEG discharges predict ADHD severity within individual Smith-Lemli-Opitz patients.

ABSTRACT:

Objective

We sought to examine the prevalence of EEG abnormalities in Smith-Lemli-Opitz syndrome (SLOS) as well as the relationship between interictal epileptiform discharges (IEDs) and within-subject variations in attentional symptom severity.

Methods

In the context of a clinical trial for SLOS, we performed cross-sectional and repeated-measure observational studies of the relationship between EEG findings and cognitive/behavioral factors on 23 children (aged 4-17 years). EEGs were reviewed for clinical abnormalities, including IEDs, by readers blinded to participants' behavioral symptoms. Between-group differences in baseline characteristics of participants with and without IEDs were analyzed. Within-subject analyses examined the association between the presence of IEDs an

SUBMITTER: Schreiber JM 

PROVIDER: S-EPMC4117167 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature