Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions.

ABSTRACT:

Objective

The link between CNS penetration of antiretrovirals and AIDS-defining neurologic disorders remains largely unknown.

Methods

HIV-infected, antiretroviral therapy-naive individuals in the HIV-CAUSAL Collaboration who started an antiretroviral regimen were classified according to the CNS Penetration Effectiveness (CPE) score of their initial regimen into low (<8), medium (8-9), or high (>9) CPE score. We estimated "intention-to-treat" hazard ratios of 4 neuroAIDS conditions for baseline regimens with high and medium CPE scores compared with regimens with a low score. We used inverse probability weighting to adjust for potential bias due to infrequent follow-up.

Results

A total of 61,938 individuals were followed for a median (interquartile range) of 37 (18, 70)

SUBMITTER: Caniglia EC 

PROVIDER: S-EPMC4117168 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature