Antibodies to single glycolipids and glycolipid complexes in Guillain-Barre syndrome subtypes.

ABSTRACT:

Objective

To comprehensively investigate the relationship between antibodies to single glycolipids and their complexes and Guillain-Barré syndrome subtypes and clinical features.

Methods

In acute sera from 199 patients with Guillain-Barré syndrome, immunoglobulin G (IgG) antibodies to glycolipids and ganglioside complexes were tested using ELISA against individual antigens from single glycolipids including gangliosides (LM1, GM1, GM1b, GD1a, GalNAc-GD1a, GD1b, GT1a, GT1b, GQ1b) and a neutral glycolipid, asialo-GM1 (GA1), and antigens from the combination of 2 different glycolipids. Based on serial nerve conduction studies, the electrodiagnoses were as follows: 69 demyelinating subtype, 85 axonal subtypes, and 45 unclassified.

Results

Significant associations were dete

SUBMITTER: Shahrizaila N 

PROVIDER: S-EPMC4117169 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature