Early developmental trajectories associated with ASD in infants with tuberous sclerosis complex.

ABSTRACT:

Objective

We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder (ASD) in this high-risk population.

Methods

Infants with TSC and typically developing controls were recruited as early as 3 months of age and followed longitudinally until 36 months of age. Data gathered at each time point included detailed seizure history, developmental testing using the Mullen Scales of Early Learning, and social-communication assessments using the Autism Observation Scale for Infants. At 18 to 36 months, a diagnostic evaluation for ASD was performed using the Autism Diagnostic Observation Schedule.

Results

Infants with TSC demonstrate

SUBMITTER: Spurling Jeste S 

PROVIDER: S-EPMC4117170 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature